TRANSLATIONAL PHYSIOLOGY Enteric glia and neuroprotection: basic and clinical aspects
نویسندگان
چکیده
Roberto De Giorgio, Fiorella Giancola, Elisa Boschetti, Hind Abdo, Bernard Lardeux, and Michel Neunlist Department of Clinical Medicine and Digestive Diseases and Internal Medicine; and Centro Unificato di Ricerca BioMedica Applicata (C.R.B.A.); and Department of Biochemistry “G. Moruzzi,” University of Bologna, Italy; and Institut National de la Santé et de la Recherche Médicale U913, Université de Nantes-Faculté des Sciences et Techniques, Institut des Maladies de l’Appareil Digestif, Clinique de chirurgie digestive, CHU Nantes, France
منابع مشابه
Enteric glia and neuroprotection: basic and clinical aspects.
The enteric nervous system (ENS), a major regulatory system for gastrointestinal function, is composed of neurons and enteric glial cells (EGCs). Enteric glia have long been thought to provide only structural support to neurons. However, recent evidence indicates enteric glia-neuron cross talk significantly contributes to neuronal maintenance, survival, and function. Thus damage to EGCs may tri...
متن کامل5-HT4-mediated neuroprotection: a new therapeutic modality on the way?
ENTERIC NEURONS HAVE A HARD LIFE. Unlike their counterparts in the central nervous system, enteric neurons lack the protection against mechanical damage that a hard skull and the cushioning of cerebrospinal fluid provide. Myenteric neurons, moreover, must also endure the shearing and pressure that accompany their location between the circular and longitudinal layers of smooth muscle. Even submu...
متن کاملVagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells.
The enteric nervous system may have an important role in modulating gastrointestinal barrier response to disease through activation of enteric glia cells. In vitro studies have shown that enteric glia activation improves intestinal epithelial barrier function by altering the expression of tight junction proteins. We hypothesized that severe injury would increase expression of glial fibrillary a...
متن کاملEnteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases
The word "glia" is derived from the Greek word "γλoια," glue of the enteric nervous system, and for many years, enteric glial cells (EGCs) were believed to provide mainly structural support. However, EGCs as astrocytes in the central nervous system may serve a much more vital and active role in the enteric nervous system, and in homeostatic regulation of gastrointestinal functions. The emphasis...
متن کاملRole of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function.
The role of enteric glia in gastrointestinal physiology remains largely unexplored. We examined the actions of the gliotoxin fluorocitrate (FC) on intestinal motility, secretion, and inflammation after assessing its efficacy and specificity in vitro. FC (100 microM) caused a significant decrease in the phosphorylation of the glucose analog 2-[N-(7-nitrobenz-2-oxa-1,3-diaz-4-yl)amino]-2-deoxyglu...
متن کامل